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10.1002/cbic.201500340

It has previously been observed that increased GSK-3 expression and activity in cell and mouse models of AD are associated with the upregulation of p-tau at Ser396 and Ser404, accompanied by a high rate of apoptosis [20]

The resulting cDNA was preamplified with 12 thermal cycles using the Fluidigm Preamp Master Mix and Delta Gene Assays according to manufacturers protocol

[PMC free article] [PubMed] [Google Scholar] 7.Hoebel BG, Teitelbaum P

There was no significant difference between the weights of the animals at the beginning of the experiment

This method of testing seems like a good idea because its minimally invasive and readily testable