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Functions of MC4R signaling in the NAc in yawning/stretching behaviors Yawning is characterized by a sequence of respiratory phases involving a long, deep inhalation followed by rapid expiration, typically accompanied by wide mouth opening and closed eyes (Gupta and Mittal, 2013
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Researchers specifically investigating MC4R-mediated biology often use MT-2 as the non-selective melanocortin agonist probe, with multi-receptor activity accounted for in the experimental design

Affiliation: the University of Messina

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