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Arsenic as an environmental and human health antagonist: A review of its toxicity and disease initiation

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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )

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Future studies should aim to integrate spatialtemporal mapping, lineage tracing, and multi-omics profiling to better delineate Treg dynamics during bone healing

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