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doi: 10.7326/AITC202007070 63 MeiL.WangJ.HaoY.ZengX.YangY.WuZ.et al

Higher doses produce increased incidence and severity of gastrointestinal symptoms, which explains why clinical protocols use gradual dose escalation starting at 0.25 mg weekly and incrementally increasing every 4 weeks
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Injections typically offer higher bioavailability since they bypass the digestive process

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