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doi: 10.1038/s41590-019-0352-y 13 Galvn-PeaSONeillLA

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The NICE guideline recommends that doctors first use one of the primary tests for B12

Ramos describes a panel of gut-barrier biomarkers used to evaluate barrier integrity and the immune response to its breakdown: Zonulin antibodies reflecting activity of the key tight-junction regulator

Physical Symptoms of Vitamin B12 Deficiency Fatigue and weakness Pale skin Shortness of breath Nerve problems Mouth ulcers Digestive issues Vision problems Mobility difficulties Cognitive Symptoms of Vitamin B12 Deficiency Peripheral Neuropathy Cognitive Disturbances Memory Problems Reversible Dementia Confusion Decreased Problem Solving Psychiatric Symptoms of Vitamin B12 Deficiency Depression Anxiety Intrusive Thoughts Irritability Psychosis Inattention Insomnia Panic attacks Treatment of Vitamin B12 Deficiency It has been observed that oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms