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Anaphylactic shock and death have been reported after parenteral Vitamin B 12 administration

Deficiency may leads to cognitive decline and vascular risk factors in neuropsychiatric disorders

Vitamin B 6 , folate, and vitamin B 12 regulate blood levels of homocysteine (see Homocysteine metabolism and Figure 1 above) an amino acid derived from methionine that may be associated with cognitive decline (155)

doi: 10.1016/j.tifs.2022.03.020 [DOI] [Google Scholar] 20.Albuquerque PBS, de Oliveira WF, Dos Santos Silva PM, Dos Santos Correia MT, Kennedy JF, Coelho L

Kurhaluk N, Bojkova B, Radkowski M et al (2018c) Melatonin and metformin diminish oxidative stress in heart tissue in a rat model of high fat diet and mammary carcinogenesis