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Severe oxidative stress can overcome the ability of the cell to reduce GSSG to GSH leading to accumulation of GSSG

A rational approach to this objective combines the principles of pharmacokinetics with pharmacodynamics to clarify the dose-effect relationship ( Figure 31 )

The K d for the reaction between RT and GSH is 3.7 mM

Psychological dependence is often mentioned as a reason for more frequent dosage

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In August 2023, the FDA approved natalizumab-sztn, a biosimilar for natalizumab, based on the Antelope phase III randomized controlled trial (49)