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Treatment with dopamine antagonists tends to alleviate these positive symptoms

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doi:10.1021/jf100716t

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

10.1101/gad.1783809 [DOI] [PMC free article] [PubMed] [Google Scholar] Kato M., Yoshimura S., Kokuzawa J., Kitajima H., Kaku Y., Iwama T., et al