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(K) heatmap showing relative expression of a ILC2-related genes between melatonin and vehicle treated cell populations

Here we present the results of STEMS, a prospective, therapeutic exploratory, non-randomized, open-label, single-dose-finding phase 1 clinical trial (NCT03269071, EudraCT 2016-002020-86), performed at San Raffaele Hospital in Milan, Italy, evaluating the feasibility, safety and tolerability of intrathecally transplanted human fetal NPCs ( hf NPCs) in 12 patients with PMS (with evidence of disease progression, Expanded Disability Status Scale 6.5, age 1855 years, disease duration 220 years, without any alternative approved therapy)

Springer, Berlin Heidelberg, pp 2941 Sasseville VG, Mansfield KG, Brees DJ (2014) Safety biomarkers in preclinical development: translational potential

, Morcuende, R

Antitumour drugs Antitumor drugs exert a therapeutic effect by inhibiting or killing tumor cells in the body

& Soto, C