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But theres no evidence that these compounds have comparable effects, likely because theyre poorly absorbed, and only minimally convert to the active form

doi: 10.1016/j.molmed.2004.09.003

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Metabolism generates the substrates for, and natural inhibitors of, ferroptosis For ferroptosis to occur, specific lipids must undergo oxidation, and natural mechanisms for blocking accumulation of oxidized lipids must become compromised (Figure 2)