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Status Not FDA-approved as of June 2026

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[DOI] [PMC free article] [PubMed] [Google Scholar] 355

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This strategy, when combined with proper labeling, reduces waste and improves cost efficiency in research settings by allowing multiple withdrawals from a single vial

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In antinociception assays, 7-hydroxymitragynine exhibits 40-fold greater potency than mitragynine and tenfold greater potency than morphine 16,17 , whereas mitragynine is less potent than morphine in antinociceptive assays 18

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The standard 250-500 mcg per day remains appropriate

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