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Further investigations revealed that ATF2 overexpression significantly elevated both CENPT mRNA and protein levels (fig S11E/G), while ATF2 knockdown (sh-ATF2) suppressed CENPT expression in RCC cell lines (fig S11F/H)

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Their findings indicated that SCFAs can stimulate intestinal L-cells to release the GLP-1

ADCs, as an innovative targeted therapy strategy, have become a significant breakthrough in cancer treatment

When BBR sulfate was administered rectally, the average bioavailabilities were 17.0% at 1 mg/kg, 24.3% at 3 mg/kg, and 12.3% at 10 mg/kg as BBR, respectively