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Neither replaces the other's function
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A cohort study investigating the non-HDL-C/HDL-C ratio in patients with sepsis revealed a U-shaped relationship with 28-day mortality, both excessively high and low ratios were associated with increased mortality (109), highlighting the importance of monitoring this ratio
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This could be attributed to poor drug permeability through the bloodbrain barrier and to the enrollment of patients without a molecular selection
