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Ferroptosis inhibitors are being explored as an alternative strategy to a new treatment for FECD

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Additionally, DNA hypermethylation can also disrupt the balance between the active and repressed histone marks of stem-cell-related genes (H3K4me3, H3K27me3) by binding to their cancer-specific promoter and blocking transcription factors from binding, consequently inducing an abnormally silenced state of the gene and chromosome instability [12,70]

Data availability The high-throughput sequencing data have been deposited in the NCBI Sequence Read Archive (PRJNA1046659, Data from all other experiments are provided as a supplementary csv file