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Of note, the FDA-approved non-phenolic antioxidant edaravone has been preclinically shown to increase Nrf2 levels in ALS patients (Ohta et al

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Cells were imaged in fresh FluoroBrite DMEM supplemented with 4 mM glutamine, 1 mM sodium pyruvate, 10% FBS and penicillin (100 U ml 1 )/streptomycin (100 g ml 1 )/fungizone (0.25 g ml 1 )

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