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Mechanisms involved are thought to include tracheal microaspiration of acid stimulating bronchospasm 30 and increased airway hyper-reactivity associated with acid reflux into the lower esophagus

It has been shown to promote healing by resolving vessel constriction, stabilizing the primary platelet plug, and resolving the clot
doi: 10.3389/fcell.2021.683609 Received 21 March 2021 Accepted 30 April 2021 Published 09 June 2021 Volume 9 - 2021 Edited by Jiri Novotny, Charles University, Czechia Reviewed by Flavio Maina, Aix-Marseille Universit, France
doi: 10.1590/198053146760 225

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