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As a result, GO provides a specialized microenvironment where typically immiscible reagents can come together and undergo chemical reactions 278

A 2012 study demonstrated that CFH Y402H, mentioned above as conferring an increased risk of AMD development, binds peroxidized phospholipids and initiates complement activity, suggesting a connection between the long-studied complement system and lipid peroxidation [172, 173]

Normal physiological sources of acetate include bacterial fermentation in the colon which increases significantly when consuming a high fiber diet

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Formation of hexa- and decadepsipeptides via NRPS misoperation is key to form the isocereulides E, F and G, whereas peptide assembly in the biosynthesis of isocereulides A-D corresponds well to that of cereulide differing that L- O -Val is substituted by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D-O-Leu by D-O-Val (isocereulide B) due to a relaxed substrate specificity of the A domains and/or an inefficient proof reading by CesT