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Additional information for health professionals about these and other dietary supplements are maintained on the NIH Office of Dietary Supplements Fact Sheet, Dietary Supplements for Primary Mitochondrial Disorders ( CONCLUSION Despite the absence of randomized controlled trials evaluating mitochondrial medicine empiric therapies to stabilize and/or improve health mitochondrial disease, progress has been made to identify potentially beneficial compounds with a high benefit-to-risk ratio that are generally well-tolerated for patients with inherited PMDs

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