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A 2022 scientific review published in the National Library of Medicine confirmed that nasal delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimising systemic exposure

2.3 Anthraquinones Rhein, an anthraquinone derivative of Rheum palmatum L

& Mitragotri, S

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Lewis R.D., Laing E.M

One important aspect of lipid peroxidation is the generation of hydroxyl radicals (OH), which can be fatal to cells if they accumulate excessively (54)