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This figure shows plots of pH versus volume of base added for the titration of 50.0 mL of a 0.100 M solution of a strong acid (HCl) and a weak acid (acetic acid) with 0.100 M NaOH

To overcome this limitation and confirm the benefit of BUP-XR 300-mg maintenance dose observed in the OI, a clinical study is currently ongoing to compare the efficacy, safety, and tolerability of the 100-mg versus 300-mg BUP-XR maintenance doses in participants with high opioid tolerance, including those who inject opioids and/or use high doses of opioids