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For example, receptor activator of nuclear factor-kappa B ligand (RANKL) is a protein produced by osteoblasts with a key role in regulating bone remodeling

Areas of uncertainty in toxicity values generally include extrapolation from controlled high-dose animal studies to the human general population (including potentially sensitive subgroups) and generally lower exposure levels, determining if rodent endpoints are relevant to humans (e.g., tumors in the Zymbals gland of rodents), route-to-route extrapolation if toxicity values are lacking for certain exposure pathways, extrapolation from shorter-duration exposure studies to chronic or lifetime risk, and data gaps in the underlying toxicity database

The trial included 127 adult follicular lymphoma patients who had undergone a median of three prior lines of therapy

More recently, EVs derived from glioblastoma (GBM) cells were shown to facilitate transformation of reactive astrocytes and promote tumor growth [150]

The study highlights the excellent light absorption and ROS generation capacity of the material, allowing targeted tumour cell damage while sparing healthy tissues [56]

Recent advancements in peptide-based hydrogels Recent research has achieved remarkable advances in the functionalization and performance of peptide hydrogels for wound healing