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Dardente et al., 2008

Isotretinoin Isotretinoin: Examination and Clinical Applications Overview Isotretinoin is a systemic retinoid medication derived from vitamin A, used primarily to treat severe or refractory acne, but with broader implications for epithelialcell differentiation, sebum regulation, and inflammatorysignaling pathways

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Indeed, both activated microglia and astrocytes cluster at sites of A deposition and express a wide range of inflammatory mediators including cytokines and chemokines and cyclooxygenase [54]

TLR binding to ligands induces the formation of dimers or conformational changes that activate TLR signaling, recruit downstream signaling molecules, and ultimately lead to the activation of NF-B and MAPK signaling, among others