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Accumulation of the toxic metabolite can then exert untoward effects on key cellular structures and functions (Figure 1)

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Oxidation of DCVC to DCVC sulfoxide followed by formation of a glutathione S -conjugate resulting from the reaction of DCVC sulfoxide with GSH may also lead to oxidative stress (Lash et al., 1994, Sausen and Elfarra, 1991)

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Am Fam Physician (2016) 94(2):10613