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CHAC2 expression is also closely linked to several genetic mutations prevalent in breast cancer, most commonly TP53, as well as CDH1, BIRC6, DYNC2H1 and UTRN ( Thus, like CHAC1, CHAC2 represents an intriguing and complex target for further cancer research

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[DOI] [PubMed] [Google Scholar] 57.Chakraborty S, Singh OP, Dasgupta A, et al

CHAC1 can induce ferroptosis independently of ER stress, primarily by depleting GSH

In females, it appears that in vivo short-term fluoxetine treatment increases systemic concentrations of estrogen 22 whereas long-term treatment appears to reduce it 21,38,39