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Similarly, the structurally distinct LIPE inhibitor BAY also reduced pSer129 S:total S of the triplication neurons toward that of the corrected neurons (Supplementary Fig

When the pentamer binds to an activated lipid membrane, initially using its calcium-dependent binding specificity for ligands expressing phosphocholine, biochemical forces lead to its dissociation, inducing structural rearrangements that expose a cryptic binding site on the dissociated CRP monomers for cholesterol molecules found in lipid rafts [35,65]

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The samples were spun down and 100 L of the supernatant was measured with filters 485ex 520em on a plate reader (DTX880, Multimode Detector, Beckman Coulter)