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Curcumin in vitro neuroprotective effects are mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling pathway and autophagy inhibition

In this context, we found, that treatment of the differentiated mouse hippocampal HT-22 neurons with STW3-VI supported/enhanced the growth of neurites compared to neurons incubated with medium alone (control), suggesting that these neurotrophic properties might play a role in its positive effects on depression in vivo

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