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In the livers of patients with Wilson disease, as well as in corresponding animal models, both copper accumulation leading to cuproptosis and iron overload causing ferroptosis have been well documented
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In addition to studies on cell and mouse models, resveratrol supplementation in T2DM patients improved glycaemic control by reducing insulin resistance, which significantly alleviated chronic inflammation and oxidative stress in diabetic patients [143]
The supplement may also interact with certain chemotherapy drugs, so cancer patients should always discuss supplementation with their oncologist before use
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Nature 507 , 315 (2014)
