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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Yu D.S., Hsieh D.S., Chang S.Y

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