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Moreover, NAMPT activity is crucial for the beneficial effects of calorie restriction, including improved oxidative stress management, mitochondrial biogenesis, and metabolic adaptation, as reported in a study involving Sprague-Dawley rats 213

Pain Animal studies have shown beneficial effects of B12 on the regeneration of nerves and the inhibition of pain-signalling pathways, including cyclooxygenase enzymes

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Clinical evidence supports the efficacy of ES and PRP in promoting nerve regeneration and functional recovery (Figure 1)

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doi: 10.1177/000331979704800111