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Remarkably, PD is not the only disease associated with -Syn amyloid formation

Pregnancy and lactation : Semaglutide is generally not recommended during pregnancy (due to its unknown side effects on fetal development) and breastfeeding

Kong EF, Tsui C, Kucharkov S, Van Dijck P, Jabra-Rizk MA

A novel EP300 mutation associated with Rubinstein-Taybi syndrome type 2 presenting as combined immunodeficiency

If headaches persist beyond 3 to 4 days, consider reducing the dose

The strongest evidence involves small older insomnia studies showing modest short-term sleep effects, but no large modern randomized trials have confirmed reliable clinical benefits or established long-term safety