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it works upstream, on an enzyme called nicotinamide N-methyltransferase (NNMT) that fat cells over-express when they become metabolically sluggish

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Reduction of NNMT activity in research models may lead to observable changes in nicotinamide metabolism, methyl group utilization, and downstream cell signaling

the 1 mg arm is the lowest measured human pharmacologic activity: Frias Lancet 2018

Research applications include: Wound healing and dermal regeneration model studies

Combining it with microneedling, for example, dramatically amplifies results: the needling creates microchannels that allow GHK-Cu to penetrate deeply into the dermis, while the peptide accelerates healing and maximizes the collagen-induction response