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Parkinsonism Relat Disord 20:13291334 [DOI] [PubMed] [Google Scholar] Corr MF et al (2023) Peripheral neuropathy in Parkinsons disease: prevalence and functional impact on gait and balance

Intramuscular replacement therapy is indicated for patients with: Significant B12 deficiency (thresholds depend on local laboratory reference ranges) Neurological symptoms or signs Pernicious anaemia Malabsorption syndromes The standard UK regimen for patients without neurological involvement involves hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance injections every 2-3 months (often 3-monthly)

Please consult with your healthcare professional before using this patch, particularly if under a doctors care or taking medication

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At some point this is no longer possible which results in a relatively rapid rise in waste products in the bloodstream and an apparent sudden onset of severe disease

After removal of duplicates, 290 unique records remained for title and abstract screening