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With 476,857 individuals across 18 different countries (propensity score matched 1:1 with pregnant controls), this is the largest study to date in this historically underserved population

were the first to describe increased whole gut permeability in patients with alcohol abuse without significant liver disease, measured by a 24 h urinary excretion of 51 Cr-EDTA, which was confirmed by increased uptake of macromolecules (inulin, EDTA and cyanocobalamin) ex vivo in jejunal biopsies (145)

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Hirota WK, Zuckerman MJ, Adler DG, et al