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Biodegradable nanoparticles containing mechanism based peptide inhibitors reduce polyglutamine aggregation in cell models and alleviate motor symptoms in a Drosophila model of Huntingtons disease

Rosenstock J, et al

Parallel research on NAD biology (e.g., precursors like NR/NMN) reinforces the centrality of NAD to mitochondrial output and recoverymechanistically aligned with 5-Amino-1MQs NNMT inhibition (Cant et al., Cell Metabolism )

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