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Combination therapies, or single agents with pleiotropic actions, are increasingly being explored to interrupt the pathological cascade at multiple levels

[4] Catalytic mechanism During the reaction, the sulfhydryl group of coenzyme A performs a nucleophilic attack on the carbonyl carbon of the acetyl group of acetyl-dihydrolipoamide (bound to dihydrolipoyl transacetylase)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Matthew J

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