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Similarly, the expression of multidrug resistance-associated protein 2 can reduce intracellular cisplatin levels by effluxing the drug, thereby diminishing its efficacy (60)

These drugs should be started at a low dose, with gradual titration up to a maximum daily dose of 3600 mg for gabapentin (1200 mg thrice a day) and 300 mg for pregabalin (dosed twice a day or thrice a day)

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Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration

1 Postulated mechanisms of medications used or being studied for treatment of hepatic encephalopathy

In Clostridioides difficile infection (CDI), MBK-01 (NCT05201079) and VE303 (NCT06237452) are leading Phase 3 candidates demonstrating efficacy and safety over fidaxomicin or donor-derived FMT (Reigadas et al., 2020)