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Several critical in vitro studies have demonstrated unique properties of ERG that are different from those of any other thiol compounds: (i) at normal physiological pH, ERG exists predominantly in the thione form rather than the thiol form 7

These results are consistent with the previous in vivo experiments using dextran with different molecular weights (3 to 2000 kDa), in which the opened BBB gaps ranged from 2.3 to 54.4 nm depending on the acoustic pressure 42,43

[DOI] [PubMed] [Google Scholar] 90.Wang R., Jiao H., Zhao J., Wang X., Lin H

doi: 10.1128/spectrum.03934-22 194 ZhaiB.OlaM.RollingT.TosiniN

For this reason, patients are often advised not to take theophylline concomitantly with St
