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These results are in line also with previous studies by Reddy et al

152 In addition, abnormal vascular and neural retinal morphology was observed in adults with isolated GH deficiency

doi: 10.1007/s11010-010-0670-8

Besides stimulating POMC transcription and ACTH biogenesis, CRH stimulates the release of ACTH from corticortophs via CRH-R1 leading to a biphasic response with the fast release of a pre-synthesized pool of ACTH, and the slower and sustained release of newly-synthesized ACTH (57)

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