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FIGURE 5 PGC-1 is a master regulator of mitochondrial biogenesis and respiration, and its expression level is a key determinant of cardiac oxidative capacity and mitochondrial content (Ventura-Clapier et al., 2008)

Front Neurol 12:775781

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doi: 10.12688/f1000research.18411.1 107 LiuLWenTXiaoYChenHYangSShenX

In a further extension of membrane-coated delivery systems, inhalable microrobots were engineered for non-invasive administration

Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production (Statzer et al., 2022)