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The crystal structure of the JAK1 FERMSH2 bound to peptides from IL10RA and IFNLR1 gave a provocative suggestion that the Box1 peptide bound to the FERM domain extends away from the FERM domain to interact with the SH2 domain of the neighboring JAK1 molecule in the crystal lattice

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Inhibition of key regulators of Gln utilization, such as GLS and MYC, or reduced Gln consumption, has been shown to increase the radiosensitivity of PCa cells, diminish CSC formation in vivo , and decrease tumor development in xenograft mouse models

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