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doi: 10.1126/science.1198469 90 ReadSMalmstrmVPowrieF

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The V327I mutation was only present in the Indian field and colony populations (5 samples)

Treatment with doxorubicin significantly reduced the tumor mass composed of HCT116 (a human colon cancer cell line) cells with gpx4 knockdown compared to the control nude mice without gpx4 knockdown [105]

This loss may contribute to the development of breast tumorigenesis (36)