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The above observation suggests that a hominid species or a modified mouse carrying the human Met gene seems essential, to examine the human therapeutic efficacy of these dimeric macrocycles in future animal experiments
On the other hand, iron is a prooxidant and can increase OS in the brain by participating in Fentons reaction and contributing to the formation of reactive oxygen species (ROS)

Changes in cellular metabolism induced by decalin-containing tetramic acids

2011;42 Suppl 2:S1621

Though in vitro data and in vivo animal data thus far is promising, more information and human trials are needed to evaluate the potential role of methylene blue as a treatment for acute and chronic brain injuries

doi: 10.1016/j.molimm.2004.09.029
