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(1995) Glutamate, calcium, and free radicals as mediators of ischemic brain damage

Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

From my ND perspective, symptoms like that often reflect more than simple irritation

SCN9A variants may be implicated in neuropathic pain associated with diabetic peripheral neuropathy and pain severity

The BRAFV600E oncogene has been shown to increase the level of the intracellular protein Kla through enhancing glycolytic flux

A couple of studies were able to demonstrate some autism patients who had decreased intake of the vitamin in their restricted diets 1,2