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In addition to cortical changes, structural alterations have been reported in subcortical regions, such as the putamina and thalami, independent of vascular abnormalities [22], while combined structural and functional abnormalities in the midbrain, thalamus and cerebellum further support the notion of widespread diabetes-related neural disruption in children [21]
In preclinical tests, the most commonly noted side effect was mild local irritation at the injection site
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