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A cofactor is a "helper molecule" that an enzyme needs to do its job

Katoh et al

However, in the context of oxidative stress and limited GSH availability, microglia can become pathologically overactive which contributes to chronic inflammation and neuronal damage

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Kosower et al [11] had previously reported that monobromobimane (a derivative of 1,5-diazobicyclo[3,3,0] actadiendiones) and non fluorescent compound with an electrophilic site, slowly reacted with glutathione to form fluorescent glutathione conjugate and that the reaction might be catalysed by glutathione transferase