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Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Exposure of healthy organs to medication is unnecessary and most often will lead to side or toxic effects which are especially an issue for medication with a narrow therapeutic index

The summarized analysis in Fig

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10.1371/JOURNAL.PONE.0083733 PLoS One 83 de MoraesC.CioffiG.WeinrebR.LiebmannJ

Otherwise, patients may not be responsive to cancer treatment
