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The increased FAO driven by carnitine leads to an increase in intracellular acetyl-CoA levels, which can be transferred to the nucleus for acetylation of histone H3K27, thereby activating GATA3 gene expression and promoting the differentiation of triple-negative breast cancer cells to the luminal cell state [36]

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With the discovery of acetyl-L-carnitine arginate, carnitines benefits have now been greatly augmented

[DOI] [PubMed] [Google Scholar] 37.Elokil A.A., Bhuiyan A.A., Liu H.-Z., Hussein M.N., Ahmed H.I., Azmal S.A., Yang L., Li S

Wang, Q., Wu, Z., Wang, F., Zhang, H., & Gan, L

"Duloxetine vs ALCAR in fibromyalgia." Clin Exp Rheumatol 2015;33(1 Suppl 88):S82-5