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Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia

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Increases in HSP60 abundance have been described acutely following in vivo SEV exposure in P7 mouse (97) and rats (125), as well as its upstream nuclear transcriptional regulator activating transcription factor 5 (ATF5)

TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis