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A similar conclusion was reached by another study published in JAMA Internal Medicine

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Although activated charcoal may be an option for patients that present within FOUR HOURS post acetaminophen ingestion, preference is generally given to intravenous N-acetylcysteine

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Biochemistry 46:22752288 Hirst J, Carroll J, Fearnley IM, Shannon RJ, Walker JE (2003) The nuclear encoded subunits of complex I from bovine heart mitochondria