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Finally, the sample size was very small

As an organic solvent, chloroform enabled largescale synthesis of pharmaceuticals, accelerating drug discovery throughout the 20th century

Nitrous oxide exposure, whether recreational or medical, can inactivate B12 and precipitate acute deficiency in susceptible individuals

It is a component of two essential cofactors used by numerous cellular enzymes, including methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate and homocysteine metabolism

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Zeller et al
